Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages.

Co-cultivation of the target T cells with the suppressor MΦs allowing cell-to-cell contact resulted in nearly significant levels of reduction in the phosphorylation levels of ERK1/2 molecules ( p = 0.08 between MAC-MΦ (+) and MAC-MΦ (−) for ERK1 and p = 0.06 between MAC-MΦ (+) and MAC-MΦ (−) for ERK2; Two-way ANOVA ( Fig. 4a, c ).

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