β-klotho expression significantly increased in lean animals with fasting (Lean fed 0.21 ± 0.09; Lean fasted 0.62 ± 0.13; p = 0.01); similar trends were observed in fasted obese animals, however the change did not reach statistical significance ( Fig 1B ).
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Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.
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