borderline significancep=0.075
During add-on therapy, that is, months 3–12, levels of all ACPAs showed greater declines among responders compared with non-responders, reaching statistical significance for anti-cVim (p=0.034) and anti-CCP IgG (p=0.025), and borderline significance for anti-CEP-1 IgG (p=0.075) ( figure 3 B).