Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.

Hum Mol Genet · 2016 · PMC4754045 · PMID 26740556

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP = 8.3 × 10 −80actually significant

Indeed, both tumour types showed highly significant retention of intron 8 sequences in association with rs700635[C] ( P = 8.3 × 10 −80 and 1.4 × 10 −34 for breast and prostate tumours, respectively; Supplementary Material, Fig.

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nominally significantno p-value reported

In conditional analysis, the association with rs1035142[T] remained nominally significant when adjusted for the effect of rs700635 ( P adj = 0.044).

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