Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.

Only the mutation L380P, which was not present in the resistance alleles isolated from the melarsoprol‐relapse patients in Uganda and Angola (Matovu et al ., 2001 ), appeared to affect drug sensitivity although this did not reach statistical significance.

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Out of a set of six reported SNPs from a reported ‘resistance allele’, none significantly impaired sensitivity to pentamidine, diminazene or melarsoprol, relative to the TbAT 1 ‐WT allele, although several combinations, and the deletion of the codon for residue F316, resulted in highly significant impairment.

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