Profiling placental and fetal DNA methylation in human neural tube defects.

There was a weak trend for differential methylation in several of our chorionic villi analyses, though overall, we noted relatively little significant change in NTDs.

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A trend for increased T homozygotes at the 677 locus was present in both NTD groups compared to CON, although this did not reach statistical significance (Table 1 ).

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