Moreover, Fezf2, a well-known master transcription factor important for corticospinal neuron development, showed a strong trend toward diminished expression in Map2k1/2;Neurod6-Cre mutants ( Chen et al., 2005 ; Chen et al., 2005 ; Molyneaux et al., 2005 ).
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Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex.
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The sentences
The validity of the screen was verified by a highly significant -2.76 ± 0.13 (p-val<0.001)-fold reduction in the expression of Map2k1 -exon 3 at the probe-level in P14 mutant samples.