Via ELISA assay we could show that total Aβ40 levels showed a trend to decrease (by about 13 %) in meprin β ko neurons ( n = 6) compared to controls ( n = 6) (Fig. 2d ); however due to the antibody specificity we were unable to detect any endogenous mouse Aβ2-40.
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Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.
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