This biologic not only abrogates the inhibitory effect of both nedocromil and ketotifen but also, interestingly, we observed that there was a strong trend for the neutralising mAb alone to promote mediator secretion when the mast cells were stimulated.
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The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.
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