Gestational hypoxia modulates expression of corticotropin-releasing hormone and arginine vasopressin in the paraventricular nucleus in the ovine fetus.

In this study, we found that LTH led to an increase in AVP mRNA hybridization signal within mpPVN neurons, whereas CRH mRNA in mpPVN neurons was not different between LTH and control fetuses, albeit there was a weak trend ( P = 0.08) for CRH being elevated.

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This included increased processing of POMC to ACTH 1–39 and increased basal plasma ACTH 1–39 with a strong trend for elevated POMC in the LTH anterior pituitary (Myers et al. 2005 ).

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