showed a trendp = 0.15
In the meantime, hemiparkinsonian rats treated with intranasal SP-GNP (p = 0.001) and intravenous SP-GNP (p = 0.02) showed a significant decrease on apomorphine-induced rotation than hemiparkinsonian rats with intranasal PBS solution treatment, while those with intranasal SP solution and blank GNP treatment showed a trend of improvement without statistical significance (p = 0.15 and p = 0.35 respectively).