Clinical efficacy of liver resection after downsizing systemic chemotherapy for initially unresectable liver metastases.

R1 resection showed a nonsignificant trend (Table 2 ).

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The presence of multiple hepatic metastases has been reported to be a very important risk factor for recurrence after liver resection, and the results in this study showed a similar trend but did not reach statistical significance [ 19 , 20 ].

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