Reduction in major bleeds did not reach statistical significance (RR 0.80, 95% CI 0.63–1.01), 45 , 53 but a substantial reduction in intracranial haemorrhage was observed (204 events in 29287 [0.70%] patients on NOAC versus 425 events in 29211 [1.45%] patients on warfarin, RR 0.48, 95% CI 0.39–0.59, p <0.0001). 52 , 54 The data of individual trials are summarised in Table 9 in the web version of this paper.
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European Primary Care Cardiovascular Society (EPCCS) consensus guidance on stroke prevention in atrial fibrillation (SPAF) in primary care.
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