A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1.

PLoS Genet · 2016 · PMC4771840 · PMID 26925970

Europe PMC DOI

hedged sentence

0.0410

closest p · 0.8× alpha

0.0410

boldest claim

The sentences

reached borderline significancep = 0.041actually significant

Although our results on low penetrance families segregating other LP alleles reached borderline significance (p = 0.041), we propose this hypothesis as a general mechanism to explain disease occurrence in the context of low penetrance Rb.

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