Effects of biphasic, basal-bolus or basal insulin analogue treatments on carotid intima-media thickness in patients with type 2 diabetes mellitus: the randomised Copenhagen Insulin and Metformin Therapy (CIMT) trial.

The interaction between metformin/placebo and insulin regimens did not reach statistical significance (p=0.085) as also reported in the detailed account of all statistical analyses at http://bendixcarstensen.com/SDC/CIMT/DOM/CIMT.pdf Glycaemic control, weight and insulin doses HbA 1c was reduced in all three groups (p<0.01), but significantly more in the biphasic compared with the aspart+detemir and detemir groups, table 2 and figure 3 .

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