Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans.

Interestingly, in contrast to what we observed before challenge, in TD subjects we recorded a strong trend towards a dominance of MF cells 48 h after typhoid diagnosis (Fig. 6 a).

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We identified a positive trend for all biomarkers between the magnitude of the decrease below baseline (area under the curve (AUC)) and their baseline levels.

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