Hypothalamic leptin action is mediated by histone deacetylase 5.

Nat Commun · 2016 · PMC4773494 · PMID 26923837

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hedged sentence

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

a strong trendP =0.075so close (0.05 < p ≤ 0.1)

Last, by using chromatin immunoprecipitation PCR in CLU177 cells with knockdown of HDAC5, we observed a strong trend towards reduced binding of STAT3 to its cis -regulatory element near the transcriptional start site of the Pomc promoter ( P =0.075, two-tailed t -test; Fig. 4l ).

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