The orientation of transcription factor binding site motifs in gene promoter regions: does it matter?

This includes the two borderline significant differences (Fig. 2 , filter/panel D1).

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While our study revealed clear evidence for the functional effect of the presence of reported TFBS-motifs on co-expression regulation of downstream genes, no significant difference was apparent with regard to motif orientation.

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The percentage of random motifs assuming actual motif compositions as background was even slightly increased, albeit at marginal significance levels only (22.7 %; Fisher exact test, p M = 0.015).

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