Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome.

Adrenalectomized male mice 6 hr after injection with another GR agonist (dexamethasone) (1 mg/kg) approached significance for feminization (p-value = 4E-4) ( GSE24256 ).

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In contrast, our evaluation of changes in 82 biosets from chemically-treated primary hepatocyte cultures, including chemicals that feminize the liver in vivo , showed that STAT5b function is rarely altered in vitro , and when altered, the changes are marginally significant compared to those seen in in vivo comparisons.

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