Touch Perception Altered by Chronic Pain and by Opioid Blockade.

Figure 2 shows that healthy subjects who received naloxone had a marginally significant increase in their ratings of pleasantness ( Fig. 2a ), but no effect on ratings of intensity ( Fig. 2b ).

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In healthy individuals, opioid blockade showed a trend toward increased ratings of touch pleasantness, while in chronic pain patients it significantly decreased ratings of touch intensity.

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