Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice.

Intriguingly, however, CHBV significantly attenuated the reduction in BAT UCP1 expression to levels that did not reach statistical significance ( Fig 4C ) and reduced the BAT NE contents ( Fig 4D ) in SGLT2i-mice 18 hours after dapagliflozin administration.

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