Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.

Elife · 2016 · PMC4786408 · PMID 26812546

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a clear trendno p-value reported

Although not statistically significant, there is also a clear trend that the E141D mutation leads to a decreased Pho8Δ60 activity at earlier time points (1-3 h) as well.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.