T-REMD simulation of d[GGGTTAGGG] reveals enormous richness of its conformational space with a clear trend to form antiparallel hairpin-like structures Since standard simulations were not efficient to study folding of the G-hairpins, we attempted an enhanced sampling method.
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Hairpins participating in folding of human telomeric sequence quadruplexes studied by standard and T-REMD simulations.
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