Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.

Moreover, GW274150 has recently been evaluated in a phase IIa clinical trial for early RA, in which the drug showed a trend toward reduction in synovial thickness (33 %; p = 0.072) and synovial vascularity (42 %; p = 0.075) vs. placebo [ 55 ].

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