RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes.

In addition, expression of mRNA encoding another M2 marker, Ym1, also showed a trend towards decreased expression in Rbpj cKO mice (Fig. 2 A), suggesting that Rbpj deficiency in the myeloid cells leads to impaired M2 polarization in vivo as manifested by reduced expression of a subset of M2-associated genes.

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