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Real-world daptomycin use across wide geographical regions: results from a pooled analysis of CORE and EU-CORE.

Ann Clin Microbiol Antimicrob · 2016 · PMC4791778 · PMID 26976128

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an increasing trendno p-value reported
An increasing trend of high-dose daptomycin (>6 mg/kg/day) prescribing pattern was observed over time.

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showed a trendno p-value reported
The results from the current analysis showed a trend toward the use of higher doses (>6 mg/kg/day) over time with high success rates for endocarditis and FBPI, which is also supported by previously published literature [ 7 , 49 , 52 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.