Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction.

PLoS One · 2016 · PMC4792392 · PMID 26977813

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an increasing trendno p-value reported

Adiponectin ( Adipoq ) gene expression showed an increasing trend in ipragliflozin-treated mice compared with vehicle-treated mice ( Fig 3D ).

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a decreasing trendno p-value reported

In addition, serum γ-GTP levels were significantly decreased in Total and Tertile 1, and a decreasing trend was observed in Tertile 3 ( S5G and S6G Figs).

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did not reach statistical significanceno p-value reported

Plasma glucagon levels in ipragliflozin-treated mice pair-fed a HFD were higher than those in vehicle-treated mice fed a HFD ad libitum , but it did not reach statistical significance ( S2I Fig ).

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