Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance.

We also quantified the number of physical contacts subjects made with the stimulus box and found a main effect of both drug ( F (1,47) = 5.89, P = 0.019) and defeat ( F (1,47) = 11.40, P = 0.001) although the interaction ( F (1,47) = 1.65, P = 0.205) did not reach statistical significance ( Fig. 2 D).

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