C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

Sci Rep · 2016 · PMC4793236 · PMID 26979938

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an increasing trendno p-value reported

MCP-1 chemokine was significantly increased in female C9orf72 −/− animals and IFNγ was significantly increased in males with an increasing trend observed in females.

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did not reach statistical significanceno p-value reported

While there was a trend toward increased IL-6 in C9orf72 −/− serum compared with WT, this difference did not reach statistical significance.

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