Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke.

Sci Rep · 2016 · PMC4794714 · PMID 26984639

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0570

boldest claim

The sentences

highly significantP = 3.9 × 10 −8actually significant

When excluding the patients with structural heart disease from the analysis, a highly significant association for AGXT2 rs16899974 was observed with any AF (P = 3.9 × 10 −8 ), and with paroxysmal AF (P = 3.0 × 10 −5 ) and chronic AF (P = 7.0 × 10 −4 ) separately.

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nominally significantP = 0.043actually significant

Nominally significant interaction was also observed between rs16899974 and prevalent cardiomyopathy on AF (P = 0.043).

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borderline significantP = 0.057so close (0.05 < p ≤ 0.1)

Moreover, rs16899974 showed a borderline significant association in the same direction for cardioembolic (CE) stroke with an OR of 1.08 (95% CI 1.00–1.16, P = 0.057).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.