Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.

There was also an increase in the expression of nuclear respiratory factor 2 ( Nrf2 ), an important DNA-binding transcription factor that regulates Tfam and mtDNA biogenesis, but this did not reach statistical significance ( Fig. 4 B ; P = 0.08).

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