Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia.

In normocapnia, this was 3.3 ± 0.7 μA cm −2 ( n = 10) and although it was lower in hypercapnia (1.6 ± 0.2 μA cm −2 ; n = 8), this was not statistically significant, although a clear trend existed ( P = 0.058 vs . normocapnia; Fig. 2 F ).

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