Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.

Linear regression analysis showed a highly significant correlation between hemispheric loss and hippocampal area loss (R2 = 0.855, p < 0.0001), with hippocampal loss tending to be greater (B = 1.209) than hemispheric area loss.

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The more severely-damaged brain may in fact be at greater risk of the deleterious effects of accidental over-cooling during HT, as the group cooled to 18 °C in the severe HI model showed a trend towards increased damage compared to the control group.

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