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Pemetrexed had significantly better clinical efficacy in patients with stage IV lung adenocarcinoma with susceptible EGFR mutations receiving platinum-based chemotherapy after developing resistance to the first-line gefitinib treatment.

Onco Targets Ther · 2016 · PMC4803239 · PMID 27051298

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showed a trendno p-value reported
In line with their finding, our study showed a trend for better PFS and a significantly longer OS in patients receiving platinum-based chemotherapy than those receiving non-platinum-based chemotherapy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.