The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

From week 14 and on, mice in both groups showed increased concentrations of anti-dsDNA autoantibodies, but on average the miR-148a group had more anti-dsDNA autoantibodies than the control group, though the difference did not reach statistical significance due to individual variations ( Fig. 6b ).

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