Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects.

The mixed-effects model used to analyze the data of repeated treatments showed that in the deficient subjects there was no change in haemolytic response in successive treatment rounds while in G6PD normal subjects there was a clear trend of increasing haemoglobin reductions across treatment rounds ( Table 3 ); although changes were extremely small, G6PD normal subjects had significantly larger reductions in the second and third rounds compared to the first round.

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