Neo-Epitopes--Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis.

Among the remaining RA patients two years after initiation of the study, 25 (38%) had non-erosive disease and 13 (20%) had erosive disease ; Baseline C2M concentrations were slightly higher in patients with erosive disease (0.23 ng/mL (0.19–0.26)) compared to patients with non-erosive disease (0.18 ng/mL (0.15–0.22) as a prognostic outcome (p = 0.011), this difference was borderline significant when adjusted for multiple testing, with the highest (median (IQR)) concentration in the erosive group and the lowest concentration in the non-erosive group.

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C3M and CRPM did not reach statistical significance in this analysis.

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The diagnostic power of C1M, C3M and CRPM was highly significant with an AUROC of 0.64 (95% CI 0.52 to 0.76), 0.73 (95% CI 0.62 to 0.84) and 0.68 (95% CI 0.57 to 0.80), respectively ( Table 2 ).

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