Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.

Expression of myc-Norbin alone caused limited lamellipodia formation and membrane ruffling that did not reach statistical significance, and no cell spreading, which was unsurprising, as the latter requires high levels of Rac1 activity ( 50 ).

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