Evidences supporting this fact include: 1) this IL18 variant showed the most significant P-value and the higher effect size; 2) the statistical significance of both rs2043055 and rs1946518 was lost after conditioning on rs360719, whereas a trend towards significance was clearly observed for rs360719 after conditioning on rs2043055 or rs1946518; 3) no improvement in the goodness of fit for the model considering the association with rs360719 was observed for any of the haplotypic models; and 4) this IL18 variant has a demonstrated functional implication in the gene expression [ 28 ].
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The sentences
Similarly, the frequency of the rs187238*G|rs19463518*C haplotype was increased in chronic cardiomyopathy individuals compared with asymptomatic patients, although the difference did not reach statistical significance either.