Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.

For early treatment versus none, highly consistent, protective point estimates were also generated for most comparisons in adults and children, but failed to reach a statistical significance for IRP [possibly due to type II errors (sample size) although they reached borderline significance for ‘any pneumonia’ (all cases)].

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When considering ‘any pneumonia’, we found a borderline significant reduced OR associated with early NAI use in all patients [adjusted OR 0·83 (95% CI 0·70–0·98)], with further borderline significant risk reductions also noted among laboratory‐confirmed cases; these findings lost a statistical significance when further stratified by patient subgroups but the point estimates remained consistent (Table 2 ).

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