Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4.

Although Tpl2 inactivation and exendin-4 alone showed a trend to reduce cytokine-induced human islet cell death, the combined use of Tpl2 inhibitor and exendin-4 showed a strong protection of human islet cell viability against proinflammatory conditions ( Figure 6c ).

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