Occurrence and prognostic significance of cytogenetic evolution in patients with multiple myeloma.

It has been associated with lymphoplasmacytic morphology and lower serum monoclonal protein concentrations in a prior study but the greater median survival (49.6 versus 38.7 months) did not reach statistical significance. 26 Its presence was associated with better 1-year overall survival in a small cohort of patients with primary plasma cell leukemia. 27 These findings suggesting more favorable outcomes may be a marker of increased cytogenetic stability in this patient population.

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