Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.

From the SMD simulations with different polyamines, a clear trend in the work values was observed (Fig. 9 C and Movie S3), suggesting that, in the WT pore, it is easier for the smaller polyamines (Put and Spd) to pass through from the filter than Spm, in agreement with our data and that of others (Bahring et al . 1997 ).

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