Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis.

Young children, as compared to older children, showed a trend of 22 % higher body weight-normalized elimination clearance and 31 % higher volume of distribution, a 20 % lower maximum concentration but a modest decrease of 14 % in total exposure.

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