Longitudinal Effects of Ketamine on Dendritic Architecture In Vivo in the Mouse Medial Frontal Cortex.

Therefore, we verified, on a per-subject basis across 7 d, that there is a significant effect of treatment on dendritic spine density (treatment: p = 0.007, F (1,16) = 9.39; day: p = 0.87, F (5,16) = 0.35; interaction: p = 0.46, F (5,16) = 0.98; two-way ANOVA), that there is an effect that was near to but did not reach statistical significance for the effect of treatment on spine formation rate (treatment: p = 0.07, F (1,16) = 3.87; day: p = 0.96, F (5,16) = 0.20; interaction: p = 0.69, F (5,16) = 0.62; two-way ANOVA), and that there is no effect of treatment on spine elimination rate (treatment: p = 0.64, F (1,16) = 0.23; day: p = 0.23, F (5,16) = 1.56; interaction: p = 0.62, F (5,16) = 0.71; two-way ANOVA).

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