Moderately significant results of two genetic variants found in the conditional quantitative trait analyses were not significant in case–control analyses, and did not lend themselves to be clinically useful predictors, with no substantial increase in the positive predictive values of the known biomarker.
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Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01.
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