In GI smooth muscles that have been examined, constitutive CPI-17 phosphory-lation is low, while MYPT1 phosphorylation at T694 and T852 is quite significant. 47 , 70 , 89 , 98 , 105 , 116 – 119 Typically, PKC inhibitors decrease the constitutive phosphorylation of CPI-17 at T38, and ROCK inhibitors decrease the constitutive phosphorylation of MYPT1 at T853. 22 , 120 However, the sensitivity of constitutive CPI-17 T38 and MYPT1 T696 phosphorylation to PKC and ROCK inhibitors varies among different GI smooth muscles.
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