Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

The genotype and phenotype associations were highly significant in the higher education stratum (main genetic effects, 1.97 × 10 −10 ≤ P main ≤8.16 × 10 −8 ) but were considerably weaker in the lower education stratum (0.008≤ P main ≤0.243).

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Two SNP × education interactions were nominally significant ( Supplementary Table 6 ): TJP2 in Europeans (rs11145488, P int =6.91 × 10 −3 ) and SHISA6-DNAH9 in Asians (rs2969180, P int =4.02 × 10 −3 ).

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