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The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia.

Leukemia · 2016 · PMC4823160 · PMID 26621337

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Interestingly, we found a higher percentage of the immunoregulatory CD56 bright CD16-CD3- ALL-NK cells at DX compared to controls although this did not reach statistical significance ( Supplementary Figure 1B ).

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