Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever--a randomized controlled noninferiority trial.

Diarrhea was significantly high in the once-daily dosage group after treatment, but the increase in the twice-daily dosage group did not reach statistical significance. However, no patient dropped out of the study due to chronic diarrhea, as the diarrhea continued for a maximum of 1 week and none of the patients were hospitalized for diarrhea treatment.

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